Cover Article
FDA Black Box Warning on Antidepressants Creates Concern for Clinicians
The FDA recently directed drug manufacturers to add a prominent warning regarding an increased risk of suicidal thoughts and behaviors for children and adolescents taking antidepressants. But for the physicians who treat these depressed children, the FDA’s actions have raised more questions than they have answered.

Selected Articles

• Can Anorexia Nervosa Be Triggered by an Infection?
• Developmental Psychopharmacology—A Perspective on New Drugs and Therapeutic Approaches

Cover Article
Adult ADHD—A Childhood Disorder Grows Up
Several lines of evidence support the contention that ADHD continues into adulthood. At a recent AMA media briefing on ADHD, Rafael Klorman, PhD, outlined why he and others believe adult ADHD is a legitimate adult disorder.

Selected Articles

• FDA Considers Stronger Warnings for Pediatric Antidepressant Use
• Atypical Antipsychotics—Enhancing Mood and Cognition

Cover Article
Is There a Biologic Connection Between Inflammatory Disease and Depression?
Depression in patients with inflammatory disease is often attributed to the patient’s inability to cope with his or her chronic disease. But studies involving patients aided by immunotherapy has challenged this theory. Researchers believe they have found strong evidence of a relationship between a molecular pathway in the brain and development of psychopathology.

Selected Articles

• Targeting Treatable Aspects of Alzheimer’s Disease
• A Novel Convulsive Therapy for Depression

Cover Article
Do You See What I Hear? Imaging Auditory Hallucinations
Swiss researchers contend that alterations in white matter fiber tracts may facilitate auditory hallucinations. During inner ear speech, the alterations “lead to abnormal activation in regions related to acoustical processing of external stimuli and may therefore account for the patients’ inability to distinguish self-generated thoughts from external stimulation,” reported Daniela Hubl, MD.

Selected Articles

• Emerging Schizophrenia Treatments Aim to Enhance NMDA Receptor Function
• Searching the Genome for Bipolar Disorder

Cover Article
The Neurologic Roots of Addiction
“The effects of a drug are not just a function of its pharmacologic properties but of the interaction between the drug and the unique biochemical characteristics of the subject’s brain,” said Nora Volkow, MD, at the American Psychiatric Association’s 157th Annual Meeting. She and colleagues have used PET and fMRI to study the brains of people with addictions.

Selected Articles

• Psychotherapy Effective in Treating Psychogenic Movement Disorders
• Anorexia Nervosa Often Runs a Chronic Course

Cover Article
Late-Life Bipolar Disorder—Guidelines and Challenges
In the absence of published guidelines on the treatment of bipolar disorder in geriatric populations, clinicians are basing treatment decisions on their own professional experience or on the scant literature that is available regarding this patient population, extrapolating from research in adults, mirroring current prescribing trends, and hoping for the best. But this sizable patient population has unique issues.

Selected Articles

• Testosterone Therapy for Men With Alzheimer’s Disease?
• Treatment of ADHD—Some Good News, Some Bad

Cover Article
Is Excessive Television Viewing in Children Linked to ADHD?
Excessive exposure to television in childhood may be linked to inattention. Researchers found that television exposure in children ages 1 to 3 is associated with attention problems at age 7. In addition, the investigators determined that each hour of television watched per day increases a child’s risk of attention problems by almost 10% by age 7.

Selected Articles

• Pathways to Depression Recovery
• Prenatal Lead Exposure May Cause Schizophrenia

Cover Article
FDA Requests Warning Statement About Risks for Antidepressants
The FDA has requested that manufacturers of 10 antidepressants include a warning statement in their labeling that recommends close observation of both adult and pediatric patients for signs of worsening depression or the emergence of suicidality, particularly at the beginning of therapy or when the dose is changed.

Selected Articles

• Brain Responds Differently to Drug, Cognitive Therapy for Depression
• Posttraumatic Stress Disorder—A Continuing Controversy in Neuropsychiatry

Cover Article
Close Adolescent Friendships May Moderate Suicidal Ideation
A nationwide study involving more than 13,000 adolescents found that close friendships play a major role in whether girls, but not boys, think about attempting suicide.

Selected Articles

• Rejection Really Hurts
• Gene Mutation Linked to Obsessive Compulsive Disorder