Cover Article
Job Strain Increases Risk of Coronary Events
Chronic job strain significantly increased the risk of recurrent coronary heart disease among middle-aged patients who returned to work after a heart attack, as reported in the October 10 JAMA.

Selected Articles

• Increased Autism Risk May Be Linked to Assisted Reproductive Technology
• Topiramate May Be Effective for Treating Patients With Alcohol Dependence

Cover Article
Overweight and Disordered Eating in Adolescents
Weight-specific socioenvironmental, personal, and behavioral variables are strong and consistent predictors of overweight status, binge eating, and extreme weight-control behaviors later in adolescence, according to a study in the November American Journal of Preventive Medicine.

Selected Articles

• Genes Linked to Suicidal Thoughts During Antidepressant Therapy
• Depression in the Workplace: Treatment Program Can Improve Productivity Outcomes

Cover Article
Is Depression Overdiagnosed?
About 121 million people are affected by depression worldwide, according to the World Health Organization, and rates of diagnosis have increased significantly in recent years. But are too many people now being diagnosed with depression?

Selected Articles

• Bipolar Disorder Diagnosis Increases in Children and Adolescents
• Cognitive Impairment Found in Patients With Treatment-Resistant Depression

Cover Article
Exploring the Relationship Between Sleep, Dreams, and Memory
Sleep benefits the most difficult learning tasks and helps extract the most important information from the brain, according to Robert Stickgold, PhD, who presented his view on the role that sleep plays in processing memories at the 21st Annual Meeting of the Associated Professional Sleep Societies.

Selected Articles

• Assessing the Impact of CATIE Results on Clinical Practice
• Angel Dust Paves a New Path to Schizophrenia Treatment

Cover Article
Black Box Slows Antidepressant Prescriptions
Findings presented at the 160th Annual Meeting of the American Psychiatric Association demonstrate the impact that the FDA's directive in 2004 has had on the prescribing beliefs of community-based practitioners, and also reveal seemingly contradictory views held by some clinicians on the matter.

Selected Articles

• Americans' Attitudes Toward Mental Health Treatment Are Changing
• DSM-IV Eating Disorder Diagnostic Criteria May Have Limited Clinical Utility

Cover Article
The Neurobiology of Free Will and Drug Addiction
Advances in brain-imaging technology have shown what many researchers have long suspected—that drug addiction is a disease of the brain, and not simply a failure of free will. One of the most instrumental leaders in that effort has been Nora Volkow, MD.

Selected Articles

• Does ADHD Treatment Lead to Later Drug Abuse?
• A Neurotrophic Hypothesis of Depression and Antidepressant Response

Cover Article
Bipolar Disorder Underrecognized, Poorly Treated
The lifetime prevalence rate of bipolar disorder in the United States may be twice as high as previously thought when the disease is viewed as a larger spectrum disorder, according to a study from the NIMH that was published in the May Archives of General Psychiatry. In addition, researchers found that many persons with bipolar disorder are not receiving appropriate treatment.

Selected Articles

• Pain Compounds Depression’s Impact for Retired NFL Players
• Gene Alterations Could Mean New Treatments for Schizophrenia

Cover Article
Does Biology Play a Role in Domestic Violence?
While considerable research into understanding the perpetrator’s mindset has focused on learned behaviors and psychosocial issues, comparatively little effort has been devoted to exploring possible biological causes of the problem, according to David George, MD.

Selected Articles

• Deep Brain Stimulation—A Treatment for Neuropsychiatric Disorders?
• Lithium Builds Gray Matter in Bipolar Brains

Cover Article
Thinking in Pictures—A Life With Autism
Many people with autism rely on the art of visual thinking to compensate for impaired communicaton and social interaction, as their imagination translates spoken and written words into full-color movies with sound. Thinking in pictures has helped Temple Grandin, PhD, excel in areas where others may not.

Selected Articles

• Is Irritability Always a Symptom of Bipolar Disorder in Children?
• Second Generation Antipsychotics Effectively Treat Schizophrenics

Cover Article
Why Atypical Antipsychotics cause Weight Gain
A new study reported in Proceedings of the National Academy of Sciences shows that orexigenic AAPDs cause weight gain by histamine H₁ receptor-linked activation of hypothalamic AMP-kinase and that the weight-gain effects of some atypical antipsychotic drugs occur via mechanisms different from those that produce therapuetic antipsychotic effects.

Selected Articles

• Severe Mental Illness Linked to Risk of Death From Cardiovascular Disease
• Should Dementia Patients Taking Antipsychotics Refrain from Driving?

Cover Article
Vitamin Supplementation and Its Effects on Cognitive Function
Researchers have found no correlation between Vitamin B supplementation and improved cognitive function, according to a meta-analysis in the January 8 Archives of Internal Medicine.

Selected Articles

• Higher Folate Intake Might Reduce Risk of Alzheimer's Disease
• Neuroimaging Insights Into Thought Disorder in Children

Cover Article
Genetic Variation May Impact Response to Antidepressants
Researchers participating in the Sequenced Treatment Alternatives to Relive Depression (Star*D) trial have identified three gene polymorphisms that affect response to the antidepressant citalopram, according to Francis McMahon, MD, and colleagues.

Selected Articles

• When Myelin Is the Cause, Might Nicotine Be the Cure?
• Combination Therapy Can Effectively Treat Depressed Adolescents